The Hotspotting the Overdose Epidemic Program, a partnership between the Staten Island Performing Provider System and the MIT Sloan School Initiative for Health Systems, is a value-based care coordination program for Overdose and Opioid Use Disorder treatment and prevention. The Hotspotting Program combines advanced predictive analytics, holistic person-centered medical and social needs support, and an innovative reimbursement paradigm. A $5 million pilot program is currently underway on Staten Island, New York. Building upon early successes in the pilot program, The Hotspotting Program is currently working to sustainably scale this value-based program beyond the pilot location and is currently implementing partnerships with the public sector, at-risk healthcare organizations and Medicaid Managed Care Organizations throughout New York State and the nation at large.